Effect of Magnesium Supplementation on Circulating Biomarkers of Cardiovascular Disease.

ABSTRACT: (1) Background: Magnesium supplementation may be effective for the prevention of cardiometabolic diseases, but the mechanisms are unclear. Proteomic approaches can assist in identifying the underlying mechanisms. (2) Methods: We collected repeated blood samples from 52 individuals enrolled in a double-blind trial which randomized participants 1:1 to oral magnesium supplementation (400 mg magnesium/day in the form of magnesium oxide) or a matching placebo for 10 weeks. Plasma levels of 91 proteins were measured at baseline with follow-up samples using the Olink Cardiovascular Disease III proximity extension assay panel and were modeled as arbitrary units in a log₂ scale. We evaluated the effect of oral magnesium supplementation for changes in protein levels and the baseline assoc

SUBMITTER: Alonso A 

PROVIDER: S-EPMC7352673 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature