Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review.

ABSTRACT: Malignant mesothelioma (MM) is mainly caused by air-born asbestos but genetic susceptibility is also suspected to be a risk factor. Recent studies suggest an increasing number of candidate genes that may predispose to MM besides the well-characterized BRCA1-associated protein-1 gene. The aim of this review is to summarize the most important studies on germline mutations for MM. A total of 860 publications were retrieved from Scopus, PubMed and Web of Science, of which 81 met the inclusion criteria and were consider for this review. More than 50% of the genes that are reported to predispose to MM are involved in DNA repair mechanisms, and the majority of them have a role in the homologous recombination pathway. Genetic alterations in tumor suppressor genes involved in chromatin, transcripti

SUBMITTER: Panou V 

PROVIDER: S-EPMC7352726 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature