Applying Tissue Slice Culture in Cancer Research-Insights from Preclinical Proton Radiotherapy.

ABSTRACT: A challenge in cancer research is the definition of reproducible, reliable, and practical models, which reflect the effects of complex treatment modalities and the heterogeneous response of patients. Proton beam radiotherapy (PBRT), relative to conventional photon-based radiotherapy, offers the potential for iso-effective tumor control, while protecting the normal tissue surrounding the tumor. However, the effects of PBRT on the tumor microenvironment and the interplay with newly developed chemo- and immunotherapeutic approaches are still open for investigation. This work evaluated thin-cut tumor slice cultures (TSC) of head and neck cancer and organotypic brain slice cultures (OBSC) of adult mice brain, regarding their relevance for translational radiooncology research. TSC and OBSC were

SUBMITTER: Suckert T 

PROVIDER: S-EPMC7352770 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature