Bcr-Abl Tyrosine Kinase Inhibitors in the Treatment of Pediatric CML.

ABSTRACT: The therapeutic approach to Chronic Myeloid Leukemia (CML) has changed since the advent of the tyrosine kinase inhibitor (TKI) imatinib, which was then followed by the second generation TKIs dasatinib, nilotinib, and, finally, by ponatinib, a third-generation drug. At present, these therapeutic options represent the first-line treatment for adults. Based on clinical experience, imatinb, dasatinib, and nilotinib have been approved for children even though the studies that were concerned with efficacy and safety toward pediatric patients are still awaiting more specific and high-quality data. In this scenario, it is of utmost importance to prospectively validate data extrapolated from adult studies to set a standard therapeutic management for pediatric CML by employing appropriate formulatio

SUBMITTER: Carofiglio F 

PROVIDER: S-EPMC7352889 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature