Molecular Epidemiology of B3 and D8 Measles Viruses through Hemagglutinin Phylogenetic History.

ABSTRACT: Of the 24 known measles genotypes, only D8 and B3 are responsible for outbreaks in the last years in Europe, Asia, and America. In this study the H gene of 92 strains circulating between 2015 and 2019 in Lombardy, Northern Italy, and 1273 H sequences available in GenBank were analyzed in order to evaluate the genetic variability and to assess the conservation of the immunodominant sites. Overall, in Lombardy we observed the presence of four different B3 and three different D8 clusters, each one of them including sequences derived from viruses found in both vaccinated and unvaccinated subjects. Worldwide, the residue 400 within the H protein, a position located within the main immune epitope, is mutated in all circulating strains that belong to the two globally endemic genotypes, B3 and D8.

SUBMITTER: Bianchi S 

PROVIDER: S-EPMC7352894 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature