Isotropic myosin-generated tissue tension is required for the dynamic orientation of the mitotic spindle.

ABSTRACT: The ability of cells to divide along their longest axis has been proposed to play an important role in maintaining epithelial tissue homeostasis in many systems. Because the division plane is largely set by the position of the anaphase spindle, it is important to understand how spindles become oriented. While several molecules have been identified that play key roles in spindle orientation across systems, most notably Mud/NuMA and cortical dynein, the precise mechanism by which spindles detect and align with the long cell axis remain poorly understood. Here, in exploring the dynamics of spindle orientation in mechanically distinct regions of the fly notum, we find that the ability of cells to properly reorient their divisions depends on local tissue tension. Thus, spindles reorient to alig

SUBMITTER: Lam MSY 

PROVIDER: S-EPMC7353144 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature