Black Sorghum Phenolic Extract Modulates Platelet Activation and Platelet Microparticle Release.

ABSTRACT: Platelet hyper-activation and platelet microparticles (PMPs) play a key role in the pathogenesis of cardiovascular diseases. Dietary polyphenols are believed to mimic antiplatelet agents by blunting platelet activation receptors via its antioxidant phenomenon. However, there is limited information on the anti-platelet activity of grain-derived polyphenols. The aim of the study is to evaluate the effects of sorghum extract (Shawaya short black 1 variety), an extract previously characterised for its high antioxidant activity and reduction of oxidative stress-related endothelial dysfunction, on platelet aggregation, platelet activation and PMP release. Whole blood samples collected from 18 healthy volunteers were treated with varying non-cytotoxic concentrations of polyphenol-rich black sorgh

SUBMITTER: Ed Nignpense B 

PROVIDER: S-EPMC7353362 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature