Unique Genetic and Histological Signatures of Mouse Pericardial Adipose Tissue.

ABSTRACT: Obesity is a major risk factor for a plethora of metabolic disturbances including diabetes and cardiovascular disease. Accumulating evidence is showing that there is an adipose tissue depot-dependent relationship with obesity-induced metabolic dysfunction. While some adipose depots, such as subcutaneous fat, are generally metabolically innocuous, others such as visceral fat, are directly deleterious. A lesser known visceral adipose depot is the pericardial adipose tissue depot. We therefore set out to examine its transcriptional and morphological signature under chow and high-fat fed conditions, in comparison with other adipose depots, using a mouse model. Our results revealed that under chow conditions pericardial adipose tissue has uncoupling-protein 1 gene expression levels which are si

SUBMITTER: Al-Dibouni A 

PROVIDER: S-EPMC7353424 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature