Zinc Oxide Exerts Anti-Inflammatory Properties on Human Placental Cells.

ABSTRACT:

Background

An aberrant and persistent inflammatory state at the fetal-maternal interface is considered as a key contributor in compromised pregnancies. Decidual endothelial cells (DECs) play a pivotal role in the control of the local decidual inflammation. The aim of the current study was to determine whether dietary supplement with zinc oxide (ZnO), due to its very low adverse effects, may be useful for modulating the inflammatory response in the first trimester of pregnancy.

Methods

The anti-inflammatory properties of ZnO in pregnancy were evaluated by in vitro tests on endothelial cells isolated from normal deciduas and on a trophoblast cell line (HTR8/Svneo). The effects of this treatment were analyzed in terms of adhesion molecule expression and inflammatory cytokine se

SUBMITTER: Balduit A 

PROVIDER: S-EPMC7353449 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature