Gut microbiota maturation during early human life induces enterocyte proliferation via microbial metabolites.

ABSTRACT:

Background

The intestinal tract undergoes a period of cellular maturation during early life, primarily characterized by the organization of epithelial cells into specialized crypt and villus structures. These processes are in part mediated by the acquisition of microbes. Infants delivered at term typically harbor a stable, low diversity microbiota characterized by an overrepresentation of various Bacilli spp., while pre-term infants are colonized by an assortment of bacteria during the first several weeks after delivery. However, the functional effects of these changes on intestinal epithelium homeostasis and maturation remain unclear. To study these effects, human neonate feces were obtained from term and pre-term infants. Fecal 16S rDNA sequencing and global untargeted LC-MS were

SUBMITTER: Dougherty MW 

PROVIDER: S-EPMC7353703 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature