Detecting fitness epistasis in recently admixed populations with genome-wide data.

ABSTRACT:

Background

Fitness epistasis, the interaction effect of genes at different loci on fitness, makes an important contribution to adaptive evolution. Although fitness interaction evidence has been observed in model organisms, it is more difficult to detect and remains poorly understood in human populations as a result of limited statistical power and experimental constraints. Fitness epistasis is inferred from non-independence between unlinked loci. We previously observed ancestral block correlation between chromosomes 4 and 6 in African Americans. The same approach fails when examining ancestral blocks on the same chromosome due to the strong confounding effect observed in a recently admixed population.

Results

We developed a novel approach to eliminate the bias caused by admi

SUBMITTER: Ni X 

PROVIDER: S-EPMC7353720 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature