Induction of ferroptosis in response to graphene quantum dots through mitochondrial oxidative stress in microglia.

ABSTRACT:

Background

Graphene quantum dots (GQDs) provide a bright prospect in the biomedical application because they contain low-toxic compounds and promise imaging of deep tissues and tiny vascular structures. However, the biosafety of this novel QDs has not been thoroughly evaluated, especially in the central nervous system (CNS). The microarray analysis provides a hint that nitrogen-doped GQDs (N-GQDs) exposure could cause ferroptosis in microglia, which is a novel form of cell death dependent on iron overload and lipid peroxidation.

Results

The cytosolic iron overload, glutathione (GSH) depletion, excessive reactive oxygen species (ROS) production and lipid peroxidation (LPO) were observed in microglial BV2 cells treated with N-GQDs, which indicated that N-GQDs could damage the

SUBMITTER: Wu T 

PROVIDER: S-EPMC7353734 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature