Controlled Human Infection With Bordetella pertussis Induces Asymptomatic, Immunizing Colonization.

ABSTRACT:

Background

Bordetella pertussis is among the leading causes of vaccine-preventable deaths and morbidity globally. Human asymptomatic carriage as a reservoir for community transmission of infections might be a target of future vaccine strategies, but has not been demonstrated. Our objective was to demonstrate that asymptomatic nasopharyngeal carriage of Bordetella pertussis is inducible in humans and to define the microbiological and immunological features of presymptomatic infection.

Methods

Healthy subjects aged 18-45 years with an antipertussis toxin immunoglobin G (IgG) concentration of <20 international units/ml were inoculated intranasally with nonattenuated, wild-type Bordetella pertussis strain B1917. Safety, colonization, and shedding were monitored over 17 days in a

SUBMITTER: de Graaf H 

PROVIDER: S-EPMC7353841 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature