Combining tissue engineering and optical imaging approaches to explore interactions along the neuro-cardiac axis.

ABSTRACT: Interactions along the neuro-cardiac axis are being explored with regard to their involvement in cardiac diseases, including catecholaminergic polymorphic ventricular tachycardia, hypertension, atrial fibrillation, long QT syndrome and sudden death in epilepsy. Interrogation of the pathophysiology and pathogenesis of neuro-cardiac diseases in animal models present challenges resulting from species differences, phenotypic variation, developmental effects and limited availability of data relevant at both the tissue and cellular level. By contrast, tissue-engineered models containing cardiomyocytes and peripheral sympathetic and parasympathetic neurons afford characterization of cellular- and tissue-level behaviours while maintaining precise control over developmental conditions, cellular gen

SUBMITTER: Sigalas C 

PROVIDER: S-EPMC7353978 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature