Characterization of the lung microbiome and exploration of potential bacterial biomarkers for lung cancer.

ABSTRACT:

Background

Emerging evidence has suggested that dysbiosis of the lung microbiota may be associated with the development of lung diseases. However, the interplay between the lung microbiome and lung cancer remains unclear. The aim of the present study was to evaluate and compare differences in taxonomic and derived functional profiles in the lung microbiota between lung cancer and benign pulmonary diseases.

Methods

Bronchoalveolar lavage fluid (BALF) samples were collected from 32 patients with lung cancer and 22 patients with benign pulmonary diseases, and further analyzed by 16S rRNA amplicon sequencing. The obtained sequence data were deeply analyzed by bioinformatics methods.

Results

A significant differentiation trend was observed between the lung cancer and contr

SUBMITTER: Cheng C 

PROVIDER: S-EPMC7354118 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature