The prevalence and prognostic significance of estrogen receptor beta expression in non-small cell lung cancer.

ABSTRACT:

Background

Estrogen receptor beta (ERβ) is the predominant estrogen receptor (ER) expressed in non-small cell lung cancer (NSCLC); however, due to methodological disparities among prior studies, the prognostic value of ERβ expression in NSCLC remains unclear. Our objective was to apply improved detection and analysis techniques to assess the prognostic value of ERβ expression in NSCLC.

Methods

A tissue microarray (TMA) was used which contained resected and biopsy specimens from 299 patients diagnosed at a single center with stages I-IV NSCLC. Sections of this array were stained using high-sensitivity fluorescence immunohistochemistry, with the well-validated PPG5/10 monoclonal antibody. Digital images of the stained array slides were analyzed using software-based image analy

SUBMITTER: Enwere EK 

PROVIDER: S-EPMC7354142 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature