Predicting brain metastasis in early stage non-small cell lung cancer patients by gene expression profiling.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) is the most common cause of cancer-death due to early metastatic spread, in many cases primarily to the brain. Organ-specific pattern of spread of disease might be driven by the activity of a specific signaling pathway within the primary tumors. We aimed to identify an expression signature of genes and the relevant signaling associated with the development of brain metastasis (BM) after surgical resection of NSCLC.

Methods

Rapidly frozen NSCLC surgical specimens were procured from tumor banks. RNA was extracted and analyzed by RNA-sequencing (Illumina HiSeq 2500). Clinical parameters and gene expression were examined for differentiating between patients with BM, patients with metastases to sites other than brain, and patients who

SUBMITTER: Kamer I 

PROVIDER: S-EPMC7354143 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature