Integrative approach to cytologic and molecular diagnosis of malignant pleural mesothelioma.

ABSTRACT: The global incidence of malignant mesothelioma (MM) causes considerable disease burden, suffering and health care costs. Beside preventive measures and ban the use of asbestos, early diagnosis would largely improve the chance of curative treatment. Current histologic criteria, however, requiring presence of invasion in the surrounding fatty tissue fail to identify MM in sufficiently early stage. Unilateral accumulation of pleural effusion is one of the earliest clinical manifestations of MM that occurs in approximately 90% of the patients. Therapeutic thoracocenthesis is necessary to remove the fluid and to relieve patients' symptoms. This effusion is easily accessible and offers early and minimally invasive diagnosis by combining cytology with immunologic, molecular- and biomarker analyse

SUBMITTER: Hjerpe A 

PROVIDER: S-EPMC7354145 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature