Predicting EGFR mutation subtypes in lung adenocarcinoma using ¹⁸F-FDG PET/CT radiomic features.

ABSTRACT:

Background

Identification of epidermal growth factor receptor (EGFR) mutation types is crucial before tyrosine kinase inhibitors (TKIs) treatment. Radiomics is a new strategy to noninvasively predict the genetic status of cancer. In this study, we aimed to develop a predictive model based on ¹⁸F-fluorodeoxyglucose positron emission tomography-computed tomography (¹⁸F-FDG PET/CT) radiomic features to identify the specific EGFR mutation subtypes.

Methods

We retrospectively studied ¹⁸F-FDG PET/CT images of 148 patients with isolated lung lesions, which were scanned in two hospitals with different CT scan setting (slice thickness: 3 and 5 mm, respectively). The tumor regions were manually segmented on PET/CT images, and 1,570 radiomic features (1

SUBMITTER: Liu Q 

PROVIDER: S-EPMC7354146 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature