The contribution of hereditary cancer-related germline mutations to lung cancer susceptibility.

ABSTRACT:

Background

Germline variations may contribute to lung cancer susceptibility besides environmental factors. The influence of germline mutations on lung cancer susceptibility and their correlation with somatic mutations has not been systematically investigated.

Methods

In this study, germline mutations from 1,026 non-small cell lung cancer (NSCLC) patients were analyzed with a 58-gene next-generation sequencing (NGS) panel containing known hereditary cancer-related genes, and were categorized based on American College of Medical Genetics and Genomics (ACMG) guidelines in pathogenicity, and the corresponding somatic mutations were analyzed using a 605-gene NGS panel containing known cancer-related genes.

Results

Plausible genetic susceptibility was found in 4.7% of lung

SUBMITTER: Liu M 

PROVIDER: S-EPMC7354149 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature