Diagnostic and Predictive Neuroimaging Biomarkers for Posttraumatic Stress Disorder.

ABSTRACT:

Background

Comorbidity between posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) has been commonly overlooked by studies examining resting-state functional connectivity patterns in PTSD. The current study used a data-driven approach to identify resting-state functional connectivity biomarkers to 1) differentiate individuals with PTSD (with or without MDD) from trauma-exposed healthy control subjects (TEHCs), 2) compare individuals with PTSD alone with those with comorbid PTSD+MDD, and 3) explore the clinical utility of the identified biomarkers by testing their associations with clinical symptoms and treatment response.

Methods

Resting-state magnetic resonance images were obtained from 51 individuals with PTSD alone, 52 individuals with PTSD+MDD, and 7

SUBMITTER: Zilcha-Mano S 

PROVIDER: S-EPMC7354213 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature