U-shaped relationship of age at diagnosis and cancer-specific mortality in primary urachal adenocarcinoma: a cohort study.

ABSTRACT:

Background

To examine the association between age at diagnosis and cancer-specific mortality (CSM) in primary urachal adenocarcinoma.

Methods

The data was obtained from the National Cancer Institute's Surveillance, Epidemiology, and End Results program (SEER). A total of 393 patients were included in the study. Smooth curve fitting and two-piecewise Cox proportional hazards models were used to identify the nonlinearity between the age at initial diagnosis and cancer-specific survival rate. Survival time between different groups was compared using Kaplan-Meier survival curves and the log-rank test.

Results

Using smooth curve fitting we found that the relationship between age at diagnosis and cancer-specific survival takes on a U-shaped curve. The inflection point that

SUBMITTER: Yu DD 

PROVIDER: S-EPMC7354349 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature