Monitoring antibody response following SARS-CoV-2 infection: diagnostic efficiency of 4 automated immunoassays.

ABSTRACT:

Introduction

SARS-CoV-2 seroconversion is important for epidemiological studies as well as contact tracing.

Material and methods

The antibody response against SARS-CoV-2 was examined in 111 patients with a positive qRT-PCR. Seroconversion was assessed using the Elecsys from Roche, the Liaison S1/S2 IgG from Diasorin, the IgG and IgA from Euroimmun, as well as the VIDAS IgG and IgM. Specificity was estimated based on the measurement of SARS-CoV-2 antibodies in 96 residual samples collected during a non-pandemic period.

Results

The highest overall sensitivity for detecting seroconversion was obtained using the Elecsys (81.1%), the Euroimmun with a combined detection of IgG/IgA (86.5%), and the VIDAS with a simultaneous measurement of IgG/IgM (78.4%).The Elecsys and the

SUBMITTER: Wolff F 

PROVIDER: S-EPMC7354376 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature