A risk score for prediction of venous thromboembolism in gynecologic cancer: The Thrombogyn score.

ABSTRACT:

Background

Gynecologic cancers are associated with high rates of venous thromboembolism (VTE), which is exacerbated by pelvic surgery and chemotherapy.

Objectives

The aim of this study was to develop and validate a risk score for VTE in patients with gynecologic cancer and to test the predictive ability of the score following addition of procoagulant biomarker data.

Patients and methods

Clinical and laboratory variables were used to develop a risk score for the prediction of VTE in patients with gynecological cancer (n = 616), which was validated in a separate cohort of patients (n = 406). Endogenous thrombin potential and D-dimer levels were determined in a subset (n = 290) of patients and used to produce an extended score in the validation cohort.

Results

Mul

SUBMITTER: Norris LA 

PROVIDER: S-EPMC7354387 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature