Evaluating the Potential for Cross-Interactions of Antitoxins in Type II TA Systems.

ABSTRACT: The diversity of Type-II toxin-antitoxin (TA) systems in bacterial genomes requires tightly controlled interaction specificity to ensure protection of the cell, and potentially to limit cross-talk between toxin-antitoxin pairs of the same family of TA systems. Further, there is a redundant use of toxin folds for different cellular targets and complexation with different classes of antitoxins, increasing the apparent requirement for the insulation of interactions. The presence of Type II TA systems has remained enigmatic with respect to potential benefits imparted to the host cells. In some cases, they play clear roles in survival associated with unfavorable growth conditions. More generally, they can also serve as a "cure" against acquisition of highly similar TA systems such as those foun

SUBMITTER: Tu CH 

PROVIDER: S-EPMC7354431 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature