Multitarget Therapeutic Strategies for Alzheimer's Disease: Review on Emerging Target Combinations.

ABSTRACT: Neurodegenerative diseases represent nowadays one of the major health problems. Despite the efforts made to unveil the mechanism leading to neurodegeneration, it is still not entirely clear what triggers this phenomenon and what allows its progression. Nevertheless, it is accepted that neurodegeneration is a consequence of several detrimental processes, such as protein aggregation, oxidative stress, and neuroinflammation, finally resulting in the loss of neuronal functions. Starting from these evidences, there has been a wide search for novel agents able to address more than a single event at the same time, the so-called multitarget-directed ligands (MTDLs). These compounds originated from the combination of different pharmacophoric elements which endowed them with the ability to interfere

SUBMITTER: Maramai S 

PROVIDER: S-EPMC7354643 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature