A Network Pharmacology Approach to Investigate the Active Compounds and Mechanisms of Musk for Ischemic Stroke.

ABSTRACT:

Objectives

This study aims to study the material basis and effective mechanism of musk for ischemic stroke (IS) based on the network pharmacology approach.

Methods

We collected the chemical components and target gene of musk from the BATMAN-TCM analytical platform and identified ischemic stroke-related targets from the following databases: DisGeNET, NCBI-Gene, HPO, OMIM, DrugBank, and TTD. The targets of musk and IS were uploaded to the String database to construct the protein-protein interaction (PPI) network, and then, the key targets were analyzed by topological methods. At last, the function biological process and signaling pathways of key targets were carried out by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and clu

SUBMITTER: Zhang C 

PROVIDER: S-EPMC7354650 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature