Mesenchymal stem cells derivatives as a novel and potential therapeutic approach to treat diabetic foot ulcers.

ABSTRACT: Diabetic foot ulcer morbidity and mortality are dramatically increasing worldwide, reinforcing the urgency to propose more effective interventions to treat such a devastating condition. Previously, using a diabetic mouse model, we demonstrated that administration of bone marrow mesenchymal stem cells derivatives is more effective than the use of bone marrow mesenchymal stem cells alone. Here, we used the aforementioned treatments on three patients with grade 2 diabetic foot ulcers and assessed their beneficial effects, relative to the conventional approach. In the present study, two doses of cell derivatives, one dose of mesenchymal stem cells or one dose of vehicle (saline solution with 5% of human albumin), were intradermally injected around wounds. Wound healing process and changes on r

SUBMITTER: Becerra-Bayona SM 

PROVIDER: S-EPMC7354732 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature