Identifying hub genes of papillary thyroid carcinoma in the TCGA and GEO database using bioinformatics analysis.

ABSTRACT:

Background

Thyroid carcinoma (THCA) is a common endocrine malignant tumor. Papillary carcinoma with low degree of malignancy and good prognosis is the most common. It can occur at any age, but it is more common in young adults. Although the mortality rate is decreased due to early diagnosis, the survival rate varies depending on the type of tumor. Therefore, the purpose of this study is to identify hub biomarkers and novel therapeutic targets for THCA.

Methods

The GSE3467, GSE3678, GSE33630 and GSE53157 were obtained from the GEO database, including 100 thyroid tumors and 64 normal tissues to obtain the intersection of differentially expressed genes, and a protein-protein interaction network was constructed to obtain the HUB gene. The corresponding overall survival informati

SUBMITTER: Wan Y 

PROVIDER: S-EPMC7354839 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature