Citrullinated histone H3, a marker of extracellular trap formation, is increased in blood of stable asthma patients.

ABSTRACT:

Background

Emerging data indicates that extracellular traps (ETs), structures formed by various immune cell types, may contribute to the pathology of noninfectious inflammatory diseases. Histone hypercitrullination is an important step in ETs formation and citrullinated histone H3 (H3cit) is considered a novel and specific biomarker of that process. In the present study we have evaluated circulating H3cit in stable asthmatics and investigated its relationship with asthma severity, pulmonary function and selected blood and bronchoalveolar lavage (BAL) biomarkers.

Methods

In 60 white adult stable asthmatics and 50 well-matched controls we measured serum levels of H3cit. In asthmatics we also performed bronchoscopy with BAL. We analyzed blood and BAL biomarkers, including inter

SUBMITTER: Kuczia P 

PROVIDER: S-EPMC7354860 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature