MAGGIE: leveraging genetic variation to identify DNA sequence motifs mediating transcription factor binding and function.

ABSTRACT:

Motivation

Genetic variation in regulatory elements can alter transcription factor (TF) binding by mutating a TF binding motif, which in turn may affect the activity of the regulatory elements. However, it is unclear which motifs are prone to impact transcriptional regulation if mutated. Current motif analysis tools either prioritize TFs based on motif enrichment without linking to a function or are limited in their applications due to the assumption of linearity between motifs and their functional effects.

Results

We present MAGGIE (Motif Alteration Genome-wide to Globally Investigate Elements), a novel method for identifying motifs mediating TF binding and function. By leveraging measurements from diverse genotypes, MAGGIE uses a statistical approach to link mutations of a

SUBMITTER: Shen Z 

PROVIDER: S-EPMC7355228 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature