The ortholog conjecture revisited: the value of orthologs and paralogs in function prediction.

ABSTRACT:

Motivation

The computational prediction of gene function is a key step in making full use of newly sequenced genomes. Function is generally predicted by transferring annotations from homologous genes or proteins for which experimental evidence exists. The 'ortholog conjecture' proposes that orthologous genes should be preferred when making such predictions, as they evolve functions more slowly than paralogous genes. Previous research has provided little support for the ortholog conjecture, though the incomplete nature of the data cast doubt on the conclusions.

Results

We use experimental annotations from over 40 000 proteins, drawn from over 80 000 publications, to revisit the ortholog conjecture in two pairs of species: (i) Homo sapiens and Mus musculus and (ii) Saccharomyc

SUBMITTER: Stamboulian M 

PROVIDER: S-EPMC7355290 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature