Preparation of a First 18F-Labeled Agonist for M1 Muscarinic Acetylcholine Receptors.

ABSTRACT: M1 muscarinic acetylcholine receptors (mAChRs) are abundant in postsynaptic nerve terminals of all forebrain regions and have been implicated in the cognitive decline associated with Alzheimer's disease and other CNS pathologies. Consequently, major efforts have been spent in the development of subtype-selective positron emission tomography (PET) tracers for mAChRs resulting in the development of several 11C-labeled probes. However, protocols for the preparation of 18F-labeled mAChR-ligands have not been published so far. Here, we describe a straightforward procedure for the preparation of an 18F-labeled M1 mAChR agonist and its corresponding pinacol boronate radiolabeling precursor and the non-radioactive reference compound. The target compounds were prepared from commercially available a

SUBMITTER: Zlatopolskiy BD 

PROVIDER: S-EPMC7355535 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature