Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological design.

ABSTRACT: Computationally driven engineering of proteins aims to allow them to withstand an extended range of conditions and to mediate modified or novel functions. Therefore, it is crucial to the biotechnological industry, to biomedicine and to afford new challenges in environmental sciences, such as biocatalysis for green chemistry and bioremediation. In order to achieve these goals, it is important to clarify molecular mechanisms underlying proteins stability and modulating their interactions. So far, much attention has been given to hydrophobic and polar packing interactions and stability of the protein core. In contrast, the role of electrostatics and, in particular, of surface interactions has received less attention. However, electrostatics plays a pivotal role along the whole life cycle of a

SUBMITTER: Vascon F 

PROVIDER: S-EPMC7355722 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature