Serum Klotho in Living Kidney Donors and Kidney Transplant Recipients: A Meta-Analysis.

ABSTRACT: α-Klotho is a known anti-aging protein that exerts diverse physiological effects, including phosphate homeostasis. Klotho expression occurs predominantly in the kidney and is significantly decreased in patients with chronic kidney disease. However, changes in serum klotho levels and impacts of klotho on outcomes among kidney transplant (KTx) recipients and kidney donors remain unclear. A literature search was conducted using MEDLINE, EMBASE, and Cochrane Database from inception through October 2019 to identify studies evaluating serum klotho levels and impacts of klotho on outcomes among KTx recipients and kidney donors. Study results were pooled and analyzed utilizing a random-effects model. Ten cohort studies with a total of 431 KTx recipients and 5 cohort studies with a total of 108 liv

SUBMITTER: Thongprayoon C 

PROVIDER: S-EPMC7355868 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature