Assessment of Raman Spectroscopy for Reducing Unnecessary Biopsies for Melanoma Screening.

ABSTRACT: A key challenge in melanoma diagnosis is the large number of unnecessary biopsies on benign nevi, which requires significant amounts of time and money. To reduce unnecessary biopsies while still accurately detecting melanoma lesions, we propose using Raman spectroscopy as a non-invasive, fast, and inexpensive method for generating a "second opinion" for lesions being considered for biopsy. We collected in vivo Raman spectral data in the clinical skin screening setting from 52 patients, including 53 pigmented lesions and 7 melanomas. All lesions underwent biopsies based on clinical evaluation. Principal component analysis and logistic regression models with leave one lesion out cross validation were applied to classify melanoma and pigmented lesions for biopsy recommendations. Our model ach

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7355922 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature