The Arg/N-Degron Pathway-A Potential Running Back in Fine-Tuning the Inflammatory Response?

ABSTRACT: Recognition of danger signals by a cell initiates a powerful cascade of events generally leading to inflammation. Inflammatory caspases and several other proteases become activated and subsequently cleave their target proinflammatory mediators. The irreversible nature of this process implies that the newly generated proinflammatory fragments need to be sequestered, inhibited, or degraded in order to cancel the proinflammatory program or prevent chronic inflammation. The Arg/N-degron pathway is a ubiquitin-dependent proteolytic pathway that specifically degrades protein fragments bearing N-degrons, or destabilizing residues, which are recognized by the E3 ligases of the pathway. Here, we report that the Arg/N-degron pathway selectively degrades a number of proinflammatory fragments, includi

SUBMITTER: Leboeuf D 

PROVIDER: S-EPMC7356051 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature