Prognostic alternative mRNA splicing signatures and associated splicing factors in acute myeloid leukemia.

ABSTRACT: The dysregulation of alternative splicing (AS) has emerged as a mechanism of acute myeloid leukemia (AML). However, the prognostic impact of AS events remains under-explored in AML. Here we report the prognostic value of AS events and associated splicing factors based on three datasets of AML patients. We defined the landscape of AS events in AML and identified 7033 AS events associated with the survival of AML patients. Based on these events, we further developed a composite 15 AS event-based prognostic signature, which was independent of the cytogenetic risk stratification and patient age, and showed a better performance than known gene expression signatures. More importantly, our new signature markedly improved the European LeukemiaNet (ELN) risk classification, indicating a broad appli

SUBMITTER: Jin P 

PROVIDER: S-EPMC7356271 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature