Recent Developments in Microfluidic Technologies for Central Nervous System Targeted Studies.

ABSTRACT: Neurodegenerative diseases (NDs) bear a lot of weight in public health. By studying the properties of the blood-brain barrier (BBB) and its fundamental interactions with the central nervous system (CNS), it is possible to improve the understanding of the pathological mechanisms behind these disorders and create new and better strategies to improve bioavailability and therapeutic efficiency, such as nanocarriers. Microfluidics is an intersectional field with many applications. Microfluidic systems can be an invaluable tool to accurately simulate the BBB microenvironment, as well as develop, in a reproducible manner, drug delivery systems with well-defined physicochemical characteristics. This review provides an overview of the most recent advances on microfluidic devices for CNS-targeted st

SUBMITTER: Teixeira MI 

PROVIDER: S-EPMC7356280 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature