Has Drug Repurposing Fulfilled its Promise in Acute Myeloid Leukaemia?

ABSTRACT: Drug repurposing is a method of drug discovery that consists of finding a new therapeutic context for an old drug. Compound identification arises from screening of large libraries of active compounds, through interrogating databases of cell line gene expression response upon treatment or by merging several types of information concerning disease-drug relationships. Although, there is a general consensus on the potential and advantages of this drug discovery modality, at the practical level to-date no non-anti-cancer repurposed compounds have been introduced into standard acute myeloid leukaemia (AML) management, albeit that preclinical validation yielded several candidates. The review presents the state-of-the-art drug repurposing approach in AML and poses the question of what has to be do

SUBMITTER: Valli D 

PROVIDER: S-EPMC7356362 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature