A Retrospective Case-Control Study of the Relationship between the Gut Microbiota, Enteropathy, and Child Growth.

ABSTRACT: The microbial communities residing in the child gut are thought to play an important role in child growth, although the relationship is not well understood. We examined a cohort of young children from Mirzapur, Bangladesh, prospectively over 18 months. Four fecal markers of environmental enteropathy (EE) (high levels of alpha-1-antitrypsin, calprotectin, myeloperoxidase, and neopterin) were examined and anthropometric measures obtained from a cohort of 68 children. The 16S rRNA gene of bacterial DNA was sequenced from stool samples and used to estimate amplicon sequence variants (ASVs). We age-matched children with poor growth to children with normal growth within 1 month and compared the change in abundance and diversity of ASVs over time. Elevated EE markers and poor linear growth in chi

SUBMITTER: Perin J 

PROVIDER: S-EPMC7356459 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature