Activation of Bone Marrow-Derived Cells and Resident Aortic Cells During Aortic Injury.

ABSTRACT:

Background

The process of aortic injury, repair, and remodeling during aortic aneurysm and dissection is poorly understood. We examined the activation of bone marrow (BM)-derived and resident aortic cells in response to aortic injury in a mouse model of sporadic aortic aneurysm and dissection.

Materials and methods

Wild-type C57BL/6 mice were transplanted with green fluorescent protein (GFP)+ BM cells. For 4 wk, these mice were either unchallenged with chow diet and saline infusion or challenged with high-fat diet and angiotensin II infusion. We then examined the aortic recruitment of GFP+ BM-derived cells, growth factor production, and the differentiation potential of GFP+ BM-derived and GFP- resident aortic cells.

Results

Aortic challenge induced recruitment of GFP+

SUBMITTER: Zou S 

PROVIDER: S-EPMC7356595 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature