Development of a Self-Emulsifying Drug Delivery System for Optimized Topical Delivery of Clofazimine.

ABSTRACT: A quality-by-design and characterization approach was followed to ensure development of self-emulsifying drug delivery systems (SEDDSs) destined for topical delivery of the highly lipophilic clofazimine. Solubility and water-titration experiments identified spontaneous emulsification capacity of different excipient combinations and clofazimine. After identifying self-emulsification regions, check-point formulations were selected within the self-emulsification region by considering characteristics required to achieve optimized topical drug delivery. Check-point formulations, able to withstand phase separation after 24 h at an ambient temperature, were subjected to characterization studies. Experiments involved droplet size evaluation; size distribution; zeta-potential; self-emulsification t

SUBMITTER: van Staden D 

PROVIDER: S-EPMC7356627 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature