Sex-Specific Associations between Gut Prevotellaceae and Host Genetics on Adiposity.

ABSTRACT: The gut microbiome has been recognized as a tool for understanding adiposity accumulation and for providing personalized nutrition advice for the management of obesity and accompanying metabolic complications. The genetic background is also involved in human energy homeostasis. In order to increase the value of nutrigenetic dietary advice, the interplay between genetics and microbiota must be investigated. The purpose of the present study was to evaluate interactive associations between gut microbiota composition and 95 obesity-related single nucleotide polymorphisms (SNPs) searched in the literature. Oral mucosa and fecal samples from 360 normal weight, overweight and obese subjects were collected. Next generation genotyping of these 95 SNPs and fecal 16S rRNA sequencing were performed. A

SUBMITTER: Cuevas-Sierra A 

PROVIDER: S-EPMC7356943 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature