Application of Post Solid-Phase Oxime Ligation to Fine-Tune Peptide-Protein Interactions.

ABSTRACT: Protein-protein interactions (PPIs) represent an extremely attractive class of potential new targets for therapeutic intervention; however, the shallow extended character of many PPIs can render developing inhibitors against them as exceptionally difficult. Yet this problem can be made tractable by taking advantage of the fact that large interacting surfaces are often characterized by confined "hot spot" regions, where interactions contribute disproportionately to overall binding energies. Peptides afford valuable starting points for developing PPI inhibitors because of their high degrees of functional diversity and conformational adaptability. Unfortunately, contacts afforded by the 20 natural amino acids may be suboptimal and inefficient for accessing both canonical binding interactions

SUBMITTER: Zhao XZ 

PROVIDER: S-EPMC7356984 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature