Fermentative N-Methylanthranilate Production by Engineered Corynebacterium glutamicum.

ABSTRACT: The N-functionalized amino acid N-methylanthranilate is an important precursor for bioactive compounds such as anticancer acridone alkaloids, the antinociceptive alkaloid O-isopropyl N-methylanthranilate, the flavor compound O-methyl-N-methylanthranilate, and as a building block for peptide-based drugs. Current chemical and biocatalytic synthetic routes to N-alkylated amino acids are often unprofitable and restricted to low yields or high costs through cofactor regeneration systems. Amino acid fermentation processes using the Gram-positive bacterium Corynebacterium glutamicum are operated industrially at the million tons per annum scale. Fermentative processes using C. glutamicum for N-alkylated amino acids based on an i

SUBMITTER: Walter T 

PROVIDER: S-EPMC7356990 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature