Ontology highlight
ABSTRACT:
SUBMITTER: Chow HY
PROVIDER: S-EPMC7357220 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Chow Hoi Yee HY Po Kathy Hiu Laam KHL Jin Kang K Qiao Guanlin G Sun Zhenquan Z Ma Wenjie W Ye Xiyun X Zhou Ning N Chen Sheng S Li Xuechen X
ACS medicinal chemistry letters 20200603 7
Daptomycin is effective in treating infections caused by antibiotic-resistant Gram-positive pathogens, including methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), vancomycin-resistant <i>Enterococci</i> (VRE), and vancomycin-resistant <i>S. aureus</i> (VRSA). Due to its distinct mechanism of action toward multidrug-resistant bacteria, daptomycin provides an attractive structural motif to generate new daptomycin-based antibiotics to combat the problem of bacterial resistance. In this stu ...[more]