Intracranial hemodynamic relationships in patients with cerebral small vessel disease.

ABSTRACT: OBJECTIVE:To investigate cerebrovascular reactivity (CVR), blood flow, vascular and CSF pulsatility, and their independent relationship with cerebral small vessel disease (SVD) features in patients with minor ischemic stroke and MRI evidence of SVD. METHODS:We recruited patients with minor ischemic stroke and assessed CVR using blood oxygen level-dependent MRI during a hypercapnic challenge, cerebral blood flow (CBF), vascular and CSF pulsatility using phase-contrast MRI, and structural magnetic resonance brain imaging to quantify white matter hyperintensities (WMHs) and perivascular spaces (PVSs). We used multiple regression to identify parameters associated with SVD features, controlling for patient characteristics. RESULTS:Fifty-three of 60 patients completed the study with a full data

SUBMITTER: Blair GW 

PROVIDER: S-EPMC7357294 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature