Molecular Mechanism of Telomere Length Dynamics and Its Prognostic Value in Pediatric Cancers.

ABSTRACT:

Background

We aimed to systematically evaluate telomere dynamics across a spectrum of pediatric cancers, search for underlying molecular mechanisms, and assess potential prognostic value.

Methods

The fraction of telomeric reads was determined from whole-genome sequencing data for paired tumor and normal samples from 653 patients with 23 cancer types from the Pediatric Cancer Genome Project. Telomere dynamics were characterized as the ratio of telomere fractions between tumor and normal samples. Somatic mutations were gathered, RNA sequencing data for 330 patients were analyzed for gene expression, and Cox regression was used to assess the telomere dynamics on patient survival.

Results

Telomere lengthening was observed in 28.7% of solid tumors, 10.5% of brain tumors, a

SUBMITTER: Wang Z 

PROVIDER: S-EPMC7357329 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature