Study of the allelic variants CYP2C9*2 and CYP2C9*3 in samples of the Peruvian mestizo population
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ABSTRACT:
SUBMITTER: Alvarado AT
PROVIDER: S-EPMC7357368 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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Study of the allelic variants CYP2C9*2 and CYP2C9*3 in samples of the Peruvian mestizo population
Alvarado Ángel Tito ÁT Muñoz Ana María AM Loja Berta B Miyasato Jessica Michiko JM García Jorge Antonio JA Cerro Roberto Andrés RA Quiñones Luis Abel LA Varela Nelson Miguel NM
Biomedica : revista del Instituto Nacional de Salud 20190901 3
Introduction: CYP2C9 metabolizes approximately 15% of the prescribed drugs. Its gene has alleles whose frequencies differ between ethnic groups and populations. The alleles CYP2C9*2 and CYP2C9*3 account for an enzyme with decreased activity and their frequencies have not been determined in the Peruvian mestizo population. Objective: To characterize the frequencies of the allelic variants *2 (rs1799853) and *3 (rs1057910) of CYP2C9 gen in the Peruvian mestizo population from Lima, Tacna y Junín. ...[more]
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